Professor Keith Cook’s research applies biomedical engineering to cardiac and pulmonary diseases. His laboratory’s goal, therefore, is to generate new devices, treatment strategies, and diagnostic tools and translate them to the clinic.
Current research projects in his group include thoracic artificial lungs, perfluorocarbon emulsions for pulmonary drug delivery, new biomaterial approaches for reducing coagulation at artificial surfaces, and PET-based diagnostic tools for right ventricular dysfunction. Of note, his laboratory was the first to produce 24 hour, week, and 30-day in vivo studies of thoracic artificial lungs, and his group is working on a artificial lung intended as destination therapy for years of respiratory support. Professor Cook currently serves as an editor of the American Society of Artificial Internal Organs Journal.
Prof. Shaoyi Jiang (Univ. of Washington, Seattle)
Professor Jiang's lab goals are to provide a fundamental understanding of molecular-level nonfouling mechanisms and to develop biocompatible and environmentally benign nonfouling materials using molecular design principles.
Over the last 10-12 years, his lab has demonstrated that zwitterionic are ultra-low fouling to complex media, are able to switch their charge, and are functionalizable, superhydrophilic, and biomimetic. His lab has also shown that zwitterionic materials prevent the formation of a collagenous capsule when implanted, prolong the circulation time of nanoparticles used for drug/gene delivery and diagnostics, preserve protein bioactivity and cell viability, and enable long-lasting, nonfouling marine coatings. Today, these zwitterionic materials are being used for a broad range of medical and engineering applications.